- Auto Inducer 2 (AI2) is formed by recylcing the molecule S-adenosylmethionine in the adenyl methyl cycle until 4, 5-dihydroxy-2, 3-pentanedione (DPD) is produced.
- 4, 5-dihydroxy-2, 3-pentanedione (DPD) is then converted into one of two forms via hydration.
- AI2 passively diffuses through the membrane.
- The Lsr transporter brings AI2 into the cell.
- AI2 is phosphorylated by LsrK.
- The AI2-phosphate binds to LsrR and causes it to release DNA which decreases transcription of the Lsr gene.
Sources:
Image: http://www.grin.com/en/doc/264621/biological-nanofactories-altering-cellular-response-via-localized-synthesis
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